Dr. Jinyao Liu: Yamaguchi University, Japan
Dr. Jinyao Liu is a distinguished lecturer at Yamaguchi University, Japan, known for his groundbreaking research on the effects of alcohol consumption and dietary imbalances on metabolic and cardiovascular health. He has made significant contributions to understanding metabolic dysfunction-associated steatohepatitis (MASH) and non-obese MASH. Dr. Liu’s development of innovative mouse models exhibiting liver fibrosis, cardiac dysfunction, and sudden cardiac death has provided valuable insights into the interplay between hepatic and cardiac sympathetic activation. His work has paved the way for novel treatment strategies addressing MASH and its systemic complications, including arteriosclerosis, chronic kidney disease, and sudden cardiac death.
Online Profiles
Dr. Liu actively shares his research contributions on several academic platforms, including ORCID, ResearchGate, and Google Scholar. These profiles feature his published works, ongoing projects, and collaborations, offering a comprehensive view of his expertise in hepatology and cardiology.
Education
Dr. Liu received his M.D. and Ph.D. from Yamaguchi University in 2003. His advanced academic training equipped him with the skills and knowledge to explore complex metabolic and cardiovascular conditions, establishing a strong foundation for his research career.
Research Focus
Dr. Liu’s primary research focus lies in unraveling the mechanisms of metabolic and cardiovascular diseases triggered by alcohol consumption and dietary patterns. His work has highlighted the role of atherogenic diets, such as low-carbohydrate, high-protein diets, and high-fat/high-cholesterol diets, in exacerbating MASH and its complications. By investigating the hepatic and cardiac sympathetic activation pathways, he has uncovered critical links between liver and heart health, contributing to the development of targeted therapies for systemic diseases.
Experience
Dr. Liu has over two decades of experience in experimental research, specializing in the development of mouse models that mimic human metabolic and cardiovascular disorders. His models have been instrumental in demonstrating the systemic effects of alcohol and diet-induced hepatic conditions, particularly their impact on cardiac function, sudden cardiac death, and advanced arteriosclerosis. His research bridges basic science with clinical applications, aiming to improve patient outcomes in hepatology and cardiology.
Research Timeline
Dr. Liu’s research journey began in 2003 with investigations into the health impacts of dietary imbalances. Between 2011 and 2018, he developed advanced mouse models that exhibited MASH and its extrahepatic complications. From 2019 onward, his work has focused on translating these findings into therapeutic strategies, addressing the systemic effects of MASH and related cardiovascular and renal conditions.
Awards & Honors
Dr. Liu has been recognized for his contributions to medical research with prestigious awards, including the Excellence in Medical Research Award from Yamaguchi University in 2010 and the Best Paper Award in Hepatology from the Japanese Society of Gastroenterology in 2018. These accolades reflect his dedication to advancing the fields of hepatology and cardiology.
Top-Noted Publications
Dr. Liu has authored numerous high-impact publications in leading journals. Notable works include his study on MASH mouse models published in the Journal of Hepatology, and his research on hepatic and cardiac sympathetic activation featured in Cardiovascular Research. His publications on dietary impacts, liver fibrosis, and sudden cardiac death have contributed significantly to understanding and managing metabolic diseases. These studies are widely cited, underscoring their importance in the medical research community.
Lethal Arrhythmogenic Role of Left Ventricular Myocardial Interstitial Fibrosis in Apolipoprotein E/Low-Density Lipoprotein Receptor Double-Knockout Mice with Metabolic Dysfunction-Associated Steatohepatitis
International Journal of Molecular Sciences
Published: December 27, 2024
DOI: 10.3390/ijms26010144
Contributors: Jinyao Liu, Yumiko Oba, Yosuke Kondo, Ryo Nakaki, Seiko Yamano
This study elucidates the arrhythmogenic effects of myocardial interstitial fibrosis in MASH mouse models, providing critical insights into the cardiac complications associated with liver diseases.
Chronic Ethanol Consumption Plus an Atherogenic Diet Cause Metabolic Steatohepatitis with Advanced Liver Fibrosis in Apolipoprotein E/Low-Density Lipoprotein Receptor Double-Knockout Mice
Alcoholism: Clinical and Experimental Research
Published: July 2022
DOI: 10.1111/acer.14852
Contributors: Jinyao Liu, Yumiko Oba, Seiko Yamano
This publication explores the combined impact of alcohol and atherogenic diets on liver health, revealing pathways leading to advanced fibrosis and metabolic dysfunction.
Alcohol Consumption Combined with Dietary Low-Carbohydrate/High-Protein Intake Increased the Left Ventricular Systolic Dysfunction Risk and Lethal Ventricular Arrhythmia Susceptibility in Apolipoprotein E/Low-Density Lipoprotein Receptor Double-Knockout Mice
Alcohol
Published: December 2020
DOI: 10.1016/j.alcohol.2020.07.003
Contributors: Jinyao Liu
This study highlights the heightened risks of cardiac dysfunction and lethal arrhythmias caused by the interaction of alcohol and specific dietary patterns in mouse models.
Alcohol Consumption in Combination with an Atherogenic Diet Increased Indices of Atherosclerosis in Apolipoprotein E/Low-Density Lipoprotein Receptor Double-Knockout Mice
Alcoholism: Clinical and Experimental Research
Published: February 2019
DOI: 10.1111/acer.13925
Contributors: Yuzo Furuta, Jinyao Liu, Ayako Himemiya-Hakucho, Koichi Yoshimura, Tatsuya Fujimiya
This research demonstrates the exacerbation of atherosclerosis indices under combined alcohol and atherogenic diet exposure, offering insights into cardiovascular risks.
Effect of Alcohol Sensitivity in Healthy Young Adults on Breath Pharmacokinetics of Acetaldehyde After Mouth Washing with Alcohol
Alcoholism: Clinical and Experimental Research
Published: November 2018
DOI: 10.1111/acer.13878
Contributors: Ayako Himemiya-Hakucho, Tsubasa Tanaka, Jinyao Liu, Tatsuya Fujimiya
This study investigates the pharmacokinetics of acetaldehyde in relation to alcohol sensitivity, providing a foundation for understanding alcohol’s effects on metabolic pathways.