Dr. Lin Shen: Associate Research Fellow & Postdoctoral Researcher, Wenzhou Medical University, China

Title/Designation: Dr
Name: Lin Shen
Current Role/Designation: Associate Research Fellow & Postdoctoral Researcher, Wenzhou Medical University
Organization/Institution Details: Zhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China
Country: China
Subject Track: Medicine
Key Areas of Expertise: Immunometabolism and its regulatory roles in multiple disease models
Award Category: Best Innovator Award

Dr. Lin Shen is an accomplished postdoctoral researcher specializing in immunometabolism and its critical regulatory roles across multiple disease models, particularly atherosclerosis and cancer. With a robust background in surgery and molecular medicine, Dr. Shen’s work bridges fundamental biological mechanisms and translational applications. Currently, Dr. Shen holds dual postdoctoral appointments at the National University of Singapore and Wenzhou Medical University, contributing to cutting-edge research on nano-drug delivery platforms and metabolic reprogramming of immune cells to combat chronic inflammatory diseases. In addition to research, Dr. Shen serves in leadership roles within clinical departments, fostering integration between research and patient care.

Online Profiles

ORCID Profile

Scopus Profile

Dr. Lin Shen is affiliated with Lishui Central Hospital, Lishui, China, and has established a strong scholarly presence with 36 publications cited by over 470 documents. With a notable h-index of 14, Dr. Shen’s research contributions have gained substantial recognition within the scientific community. His work is indexed in major databases including Scopus (Author ID: 57224404551) and ORCID, facilitating broad accessibility and citation tracking.

Education

Dr. Shen completed a Ph.D. in Surgery from Wenzhou Medical University in 2023, under the mentorship of Professor Jiansong Ji, focusing on molecular and cellular mechanisms in disease pathology. Prior to that, he earned a Master’s degree in Surgery from Shandong First Medical University in 2020, where his research was guided by Professor Bin Ning. His foundational training began with a Bachelor of Science in Clinical Medicine from the same university in 2016. This solid educational background provided Dr. Shen with a comprehensive understanding of clinical medicine, research methodologies, and translational science.

Research Focus

Dr. Shen’s research primarily investigates the interplay between immunometabolism and disease progression, with a special focus on the microenvironmental regulation within atherosclerotic plaques. His work explores innovative approaches such as enzymatic catalysis, nanozyme-based therapies, and multifunctional nanoparticles for targeted modulation of inflammation and cholesterol metabolism. By elucidating how macrophage polarization and metabolic reprogramming influence disease states, Dr. Shen aims to identify novel therapeutic targets and develop advanced nanomedicine platforms to enhance treatment efficacy in cardiovascular and oncological diseases.

Experience

Since 2023, Dr. Shen has held multiple prestigious postdoctoral research positions, including at the National University of Singapore under Professor Xiaoyuan Chen and at Wenzhou Medical University with Professors Xiaokun Li and Jiansong Ji. Beyond research, he actively contributes to clinical administration as the Assistant to the Director of the Orthopedics Department and Deputy Secretary of the Youth League Committee at the Fifth Affiliated Hospital of Wenzhou Medical University. In 2024, he was promoted to Associate Research Fellow at the same hospital, reflecting his growing impact and leadership in both research and clinical spheres.

Research Timeline & Activities

Dr. Shen’s recent projects span from 2024 to 2028 and include funded studies such as the NSFC Young Scientist Fund project on fusion protein-coated vascular stents aimed at anti-restenosis, as well as provincial grants focusing on nano-drug delivery systems and calcium carbonate-based nanoparticles for plaque microenvironment modulation. His research activities encompass molecular imaging, immune microenvironment tracking, and metabolic pathway analysis, leading to numerous publications in high-impact journals. This trajectory illustrates a focused effort to translate molecular insights into clinically relevant interventions.

Awards & Honors

Dr. Shen has been recognized with significant awards and research funding, including the prestigious National Natural Science Foundation of China Young Scientist Fund, multiple China Postdoctoral Science Foundation grants, and Zhejiang provincial scientific awards. These honors validate his innovative contributions to biomedical research, particularly in the areas of nanotechnology-based therapies and immunometabolism. Additionally, his role as a council member of the Hospital Intelligent System Construction Branch underscores his involvement in healthcare innovation beyond the laboratory.

Recent Publications

Among his extensive publication record, Dr. Shen’s 2024 article in ACS Nano, titled “NIR-II Imaging for Tracking the Spatiotemporal Immune Microenvironment in Atherosclerotic Plaques,” represents a landmark study combining advanced near-infrared imaging with immunological insights to monitor plaque progression dynamically. This work has been widely cited for its novel methodology and its implications for early diagnosis and targeted treatment of cardiovascular diseases. Dr. Shen’s research continues to push the boundaries of nanomedicine and immune system modulation.

  • Shen L, Yang Z, Zhong Y, Bi Y, Yu J, Lu Q, Su Y, Chen X, Zhao Z, Shu G, Chen M, Cheng L, Feng L, Lu C, Liu Z, Ji J. Cholesterol Targeted Catalytic Hydrogel Fueled by Tumor Debris can Enhance Microwave Ablation Therapy and Anti-Tumor Immune Response. Advanced Science. 2025 Feb. DOI: 10.1002/advs.202406975.

  • Guo X, Chen X, Ding J, Zhang F, Chen S, Hu X, Fang S, Shen L, Lu C, Zhao Z, et al. Acidic/hypoxia dual-alleviated nanoregulators for enhanced treatment of tumor chemo-immunotherapy. Asian Journal of Pharmaceutical Sciences. 2024. DOI: 10.1016/j.ajps.2024.100905.

  • Du Z, Lan C, Shen L, Tian Z, Hu H, Mei J, Feng Y, Zhai M, Yu J, Liu K, et al. Advances in multimodality imaging and the application of new cardiac imaging technologies for radiation-induced heart disease. iRADIOLOGY. 2024. DOI: 10.1002/ird3.72.

  • Chen M, Shu G, Lv X, Xu X, Lu C, Qiao E, Fang S, Shen L, Zhang N, Wang J, et al. Corrigendum to “HIF-2α-targeted interventional chemoembolization multifunctional microspheres for effective elimination of hepatocellular carcinoma”. Biomaterials. 2024. DOI: 10.1016/j.biomaterials.2024.122676.

  • Bi Y, Ying X, Chen W, Wu J, Kong C, Hu W, Fang S, Yu J, Zhai M, Jiang C, et al., Shen L. Glycerophospholipid-driven lipid metabolic reprogramming as a common key mechanism in the progression of human primary hepatocellular carcinoma and cholangiocarcinoma. Lipids in Health and Disease. 2024. DOI: 10.1186/s12944-024-02298-4.

Strengths for the Best Innovator Award

  1. Pioneering Research in Immunometabolism and Nanomedicine
    Dr. Lin Shen’s innovative work at the interface of immunometabolism and nanotechnology has paved new avenues in treating complex diseases such as atherosclerosis and cancer. His development of nano-drug delivery platforms and catalytic hydrogels showcases his ability to translate cutting-edge science into impactful therapeutic strategies.

  2. Cross-Disciplinary Expertise Bridging Basic and Clinical Sciences
    With a strong foundation in surgery and molecular medicine, Dr. Shen uniquely integrates clinical insights with molecular research. This rare combination enables him to develop solutions that are not only scientifically groundbreaking but also highly relevant to patient care and clinical applications.

  3. Successful Leadership and Collaborative Roles
    Beyond his research, Dr. Shen has taken on significant leadership roles, such as Assistant to the Director in Orthopedics and Deputy Secretary of the Youth League Committee. His ability to foster collaboration across clinical departments and research teams highlights his innovation not only in science but also in organizational development.

  4. Recognition through Prestigious Funding and Awards
    Dr. Shen’s receipt of major grants, including the National Natural Science Foundation of China Young Scientist Fund and multiple postdoctoral awards, validates the originality and potential impact of his research projects. These competitive accolades affirm his status as a leading innovator in biomedical research.

  5. High-Impact Publications with Practical Implications
    Dr. Shen’s research outputs, featured in top-tier journals like Advanced Science and ACS Nano, demonstrate significant advancements in imaging, immune modulation, and therapeutic nanotechnologies. His publications not only advance scientific knowledge but also provide practical methodologies for improving disease diagnosis and treatment.

Lin Shen, Medicine, Best Innovator Award